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Category: Aging

In Down syndrome cells, genome-wide disruptions mimic a senescence-like state | MIT News
January 11, 2022

In Down syndrome, the third copy of chromosome 21 causes a reorganization of the 3D configuration of the entire genome in a key cell type of the developing brain, a new study shows. The resulting disruption of gene transcription and cell function are so similar to those seen in cellular aging, or senescence, that the scientists leading the study found they could use anti-senescence drugs to correct them in cell...

Study links gene to cognitive resilience in the elderly | MIT News
November 15, 2021

Many people develop Alzheimer’s or other forms of dementia as they get older. However, others remain sharp well into old age, even if their brains show underlying signs of neurodegeneration. Among these cognitively resilient people, researchers have identified education level and amount of time spent on intellectually stimulating activities as factors that help prevent dementia. A new study by MIT researchers shows...

For stem cells, bigger doesn’t mean better | MIT News
November 12, 2021

MIT biologists have answered an important biological question: Why do cells control their size? Cells of the same type are strikingly uniform in size, while cell size differs between different cell types. This raises the question of whether cell size is important for cellular physiology. The new study suggests that cellular enlargement drives a decline in function of stem cells. The researchers found that blood stem...

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